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Treatment of mice with salinomycin inhibits mammary tumor growth in vivo and induces increased epithelial differentiation of tumor cells. Salinomycin (SAL) is one of the first discovered inhibitors of human cancer stem cells (CSCs), which acts via blocking the Wnt/β-catenin pathway. However, SAL has not been clinically used to treat human diseases due to its poor aqueous solubility and considerable toxicity. Salinomycin, a polyether ionophore antibiotic isolated from Streptomyces albus, has been shown to kill CSCs in different types of human cancers, most likely by interfering with ABC drug transporters, the Wnt/ β -catenin signaling pathway, and other CSC pathways.

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The purpose of our study was to determine if salinomycin could decrease cancer cell viability when combined with doxorubicin in feline sarcoma and carcinoma cells. Results We established Salinomycin is an antibiotic isolated from Streptomyces albus that selectively kills cancer stem cells (CSCs). However, the antitumor mechanism of salinomycin is unclear. This study investigated the chemotherapeutic efficacy of salinomycin in human prostate cancer PC-3 cells. We found that cytotoxicity of salinomycin to PC-3 cells was stronger than to nonmalignant prostate cell RWPE-1 Abstract Since Salinomycin (Sal) emerged its ability to target breast cancer stem cells in 2009, numerous experiments have been carried out to test Sal’s anticancer effects. What deserve to be mentioned is that Sal can efficiently induce proliferation inhibition, cell death and metastasis suppression against human cancers from different origins both in vivo and in vitro without causing Salinomycin, the first ranked drug, has recently been considered as a promising novel anti-cancer agent for targeting human cancer stem cells despite its not well-known mechanism of action (32)(33 2012-09-19 · Background Salinomycin is a polyether ionophore antibiotic that has recently been shown to induce cell death in human cancer cells displaying multiple mechanisms of drug resistance. The underlying mechanisms leading to cell death after salinomycin treatment have not been well characterized.

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Salinomycin was purchased One compound, salinomycin, reduces the proportion of CSCs by >100-fold relative to paclitaxel, a commonly used breast cancer chemotherapeutic drug. Treatment of mice with salinomycin inhibits mammary tumor growth in vivo and induces increased epithelial differentiation of tumor cells. Hypoxia and low pH are some of the major attributes of tumor milieu, enhancing anoikis evasion and therapy resistance.

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Salinomycin selectively targets cancer stem cells. The potential of salinomycin to eliminate both cancer stem cells and therapy-resistant cancer cells may characterize the compound as a novel and an efficient chemotherapeutic drug.

It effectively inhibited cell proliferation, invasion, and migration. Background and purpose: Salinomycin is a well-known inhibitor of human cancer stem cells (CSCs). However, the molecular mechanism (s) by which salinomycin targets colorectal CSCs is poorly understood.
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Of particular interest in this respect is the ionophore salinomycin, a natural product shown to be 100-fold more active against CSCs than clinically used paclitaxel. We have previously reported that synthetic Huang, Xiaoli et al. "Breast cancer stem cell selectivity of synthetic nanomolar-active salinomycin analogs.". BMC Cancer. 2016.

The following stages  Mar 11, 2021 In this podcast, Cancer.Net Associate Editor Dr. Norah Lynn Henry discusses new research presented at the 2020 San Antonio Breast Cancer  Jan 11, 2019 Salivary gland cancer is a rare cancer that forms in tissues of the gland in the mouth that makes saliva.
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Together we will beat cancer About cancer Cancer types Cancers in general Causes of cancer Coping with ca Treatment of 5 mg/kg salinomycin in mice implanted with SUM159 human breast cancer cells inhibits mammary tumor growth and induces increased epithelial  17 Aug 2017 Epithelial-mesenchymal transition (EMT) of cancer cells is widely accepted to be important for metastasis and progression, but it has also been  “To investigate its action, we developed a surrogate salinomycin drug, ironomycin, that was at least 10-fold more potent than salinomycin against CSCs in vitro and  2 Aug 2016 In parallel, it works as an antagonist on ERα in breast cancer tissue where it inhibits tumor growth in estrogen dependent breast cancer [5]. 9 Aug 2011 Salinomycin, an antibiotic potassium ionophore, has been reported recently to act as a selective breast cancer stem cell inhibitor, but the  21 Jun 2013 cancer stem cells. We investigated the impact of salinomycin on survival, colony growth, migration and invasion of the differentiated human  20 May 2015 e13565 Background: Cancer stem cells (CSCs), a small population of tumor cells responsible for tumor seeding and recurrence, are  Salinomycin is promising primarily because it has been shown to kill the cancer stem cells while at the same time enabling other drugs to more efficiently kill the  11 Aug 2015 Besides is wide effectiveness in various types of cancers, another strong point of Salinomycin is that even if it will not kill the cancer cells, it is a  The in vitro anticancer activities of salinomycin have been validated against the lung cancer cell line A549 via sulforhodamine B and colony formation assay. In addition to your Primary Treatment(s), there are other ways to inhibit tumor that may contribute to the elimination of Cancer Stem Cells by salinomycin, says   Información: Salinomicina: Nueva droga ataca a las células madre del cáncer Image comment: Cancer cells in tumors treated with salinomycin have a less  11 Mar 2021 In this podcast, Cancer.Net Associate Editor Dr. Norah Lynn Henry discusses new research presented at the 2020 San Antonio Breast Cancer  8 Apr 2020 Tumor phase: Tumors form on the skin. These tumors may develop ulcers and the skin may get infected.